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Somatic mutations in chromatin remodeler genes could modify the epigenomic landscape of CLL, but They are really unheard of On this malignancy when compared with other lymphoid neoplasms. CHD2 is mutated in five% of CLL and 7% of MBL.seventy five The histone methyltransferase SETD2 and ARID1A are mutated in a small proportion of patients. Of note,